John Jasper
Cloisterham's choirmaster, Edwin's uncle, a secret opium user, and Rosa's coercive admirer.
Edwin Drood
Jasper's young nephew, whose disappearance creates the central mystery.
Rosa Bud
Edwin's former fiancee, who recognizes Jasper's threat and escapes his control.
Neville Landless
A volatile but vulnerable newcomer whom Jasper positions as the principal suspect.
Helena Landless
Neville's protective twin and Rosa's perceptive ally.
Septimus Crisparkle
The humane Minor Canon who mentors Neville and resists the rush to judgment.
Mr. Grewgious
Rosa's practical guardian, who protects her and quietly organizes the response to Jasper.
Dick Datchery
A white-haired newcomer whose vague past and private score mark him as a disguised investigator.
Durdles
A stonemason familiar with the cathedral crypts and unknowingly useful to Jasper.
Princess Puffer
The London opium seller who recognizes Jasper and follows his trail to Cloisterham.